Zinc has an important role in skin health and its deficiency reduces immunity to evaluate levels of zinc in squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) of skin, we studied 44 BCC and 38 SCC cases together with 33 controls. Blood samples were taken and after separation of serum, levels of zinc, albumin and total protein were measured by atomic absorption albumin kit and reflectometer consecutively. Serum globulin levels were estimated by subtracting albumin from total protein levels. Zinc levels were significantly lower in cancer cases than control (P<0.001). Mean serum albumin of BCC cases was significantly more than controls (P<0.01), but in BCC cases was not significantly different. Significant correlations were seen between levels of serum zinc and albumin of SCC (r=0.507, P<0.01) and BCC(r=0.43, P<0.01) patients and controls(r=0.35,P<0.01). Mean globulin levels in cancer cases were significantly lower than control group (P<0.01).We concluded that serum zinc and globulin levels decrease in BCC and SCC of skin.

Milk thistle (Silybum marianum (L.) Gaertn) belonging to the Asteraceae family and known for its valuable secondary metabolite, silymarin. In order to get the cell suspension culture of Silybum marianum, the combination of 2,4-D and BAP hormones each with five different concentrations (0, 0.1, 1, 2 and 5 mg/L) and 3 different seedling explants (cotyledon, hypocotyl and root) was used to callus formation. High-quality callus was observed in eight different of hormone-explant combinations. Successful cell suspension culture was achieved only by using callus created from cotyledon explants treated with 0.1 mg/L 2,4-D and 5 mg/L BAP. Furthermore, the study examined the effects of 2% and 4% Serendipita indica cell wall extract as an elicitor on silymarin production in cell suspension culture at three different inoculation times (24, 48, and 72 h). After 48 h of inoculation with 2% fungal extract, the highest level of silymarin (199 ppm) was observed, which was significantly different from the control (46 ppm). The silymarin content of cells increased over time through elicitation with 4% fungal elicitor, while no similar pattern was observed with 2% fungal extract. Based on the results, the cell wall of S. indica can significantly enhance the amount of SLM in the cell suspension culture of S. marianum.

In this study a 31 y/o woman who was housewife, came from Mazandaran and lived in Behshahr is presented. Patient's complaints were diarrhea, bloating, abdominal pain and weight loss. Abdominal radiography showed loop dilatation. In primary Para clinic assessments she had Alb: 2.8, Ca: 6.4, P: 2.3 and PTH: 201. Considering malabsorption in early evaluation, upper endoscopy was done. Intestinal folds were disappeared in second and third part of duodenum in endoscopic view and duodenal biopsy was done. Then pathological assessment revealed a large accumulation of intraepithelial lymphocytes and obvious villus atrophy that was accordant to celiac sprue. She was advised to be on gluten free diet. After about 1 month, She was referred because of sever lower extremities edema. Serum albumin was checked that was 2. Enlarged mesenteric lymph nodes were detected in sonography. Considering non- responding treatment, IHC staining of intestinal biopsy was performed with celiac sprue complication suspicion.Therefore the patient was referred to chemotherapy center with the diagnosis of T-cell lymphoma following celiac sprue. She was spent 6 course chemotherapy with CHOP regimen and radiotherapy.

Basal cell carcinoma is the, most common skin cancer that has nodular, superficial, micronodular, Morpheaform, pigmented, metatypical and fibroepithelioma of Pinkus subtypes. In this report, we evaluated the efficacy of cryosurgery with liquid nitrogen for basal cell carcinoma in three patients. The response was good and patients were followed regularly. There were no recurrences after 25 months follow-up. This method is fast and appropriate for certain types of basal cell carcinomas.      

Primary cutaneous CD30+ T cell lymphoma is a rare lymphoma originally in and confined to the skin. These lymphomas usually present as a large solitary and often ulcerated nodule. Its prognosis is good and has a good response to radiotherapy. We report a 34-year-old man, who had primary cutaneous CD30+ T cell lymphoma on his face, which presented as an ulcerated nodule.    

Iran's eastern borders have been constantly affected by various events, especially the arrival of different ethnic groups in Central Asia in the form of migration or invasion. However, ancient sources provide researchers with little knowledge of such events, and this little information is specific to incidents that were widely considered a threat to the central government of Iran. Therefore, written sources do not answer the questions of archaeologists on political, military, various urban planning, and cultural interactions of Iran with its eastern neighbors. On the other hand, extensive and continuous field research that purposefully answers such questions has been limited and scattered. One of these researches is the purposeful activities that have been carried out in the middle part of the Kopet Dag-Aladagh corridor in the north of Khorasan in the last decade; and this has become the basis for the formation of other research by other researchers in this geographical area (albeit limited). "Tas Tape" is one of the sites in the northeast of Iran. Its location is in the middle part of the Kopet Dag-Aladagh corridor and the east of Quchan city. According to the results of two seasons of field research, this site is one of the important sites of the Parthian period that has been settled until the Sassanid period. Around Tas Tape, a large settlement site was identified during additional studies after archeological surveys in Quchan city. The existence of questions about the synchronicity of the settlement with the fort hill, how the two parts are related to each other, and the continuation of life until the Sassanid period led to the definition of a long-term research project to answer the questions and better understand this ancient monument. This article is based on the research conducted in the first season of this site, which includes reviewing the area of the site, geomagnetic surveys, and sounding for delimitation of the Tas Tape site. The results of this season include the identification of a site from the Parthian period with an area of 80 hectares, which consists of two parts: a) Fort mound b) Unenclosed settlement. According to preliminary results, the settlement probably was only in the Parthian period, but the fort hill was used until the Sassanid period. The Clinky pottery is the most significant cultural find on this site in terms of chronology and distribution of this type of pottery. The location of this site is also very remarkable because it is the link of the north of Kopet Dag sites, including Nisa, into the Iranian plateau.